Earlier medicines were made to release the drugs in an immediate or extended fashion. However, in recent years, pulsatile drug delivery systems (PDDS) are gaining growing interest. A pulsatile drug release, where the drug is released rapidly after a well defined lag-time at the right site of action at right time and in the right amount, could be advantageous for many drugs or therapies over conventional dosage form and results in improved patient therapeutic efficacy and compliance. These systems are designed according to the circadian rhythm of the body. Pulsatile release systems can be classified in multiple-pulse and single-pulse systems. In stimuli induced drug release is controlled by the stimuli, such as the pH or enzymes present in the intestinal tract or enzymes present in the drug delivery system and externally regulated system where release is programmed by external stimuli like magnetism, ultrasound and electrical effect. Diseases wherein PDDS are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, cancer, Diabetes, Neurological disorders and hypercholesterolemia. A product available as once a daily formulation based on pulsatile release like PulsinCap is mentioned in the review.
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